منابع مشابه
Effects of pacemaker currents on creation and modulation of human ventricular pacemaker: theoretical study with application to biological pacemaker engineering.
A cardiac biological pacemaker (BP) has been created by suppression of the inward rectifier K(+) current (I(K1)) or overexpression of the hyperpolarization-activated current (I(h)). We theoretically investigated the effects of incorporating I(h), T-type Ca(2+) current (I(Ca,T)), sustained inward current (I(st)), and/or low-voltage-activated L-type Ca(2+) channel current (I(Ca,LD)) on 1) creatio...
متن کاملPacemaker Twiddler's Syndrome
A 76-yr-old man with unipolar ventricular pacemaker, previously implanted in the right ventricular apex, presented with syncopal attack and twitching of the right pectoralis muscle. He finally was diagnosed as having Twiddler's syndrome. The patient had a pulse rate of 36/min and cannon waves in the neck veins. Chest radiography showed a dislodged pacing lead completely wrapped around the pulse...
متن کاملCreation of a biological pacemaker by cell fusion.
As an alternative to electronic pacemakers, we explored the feasibility of converting ventricular myocytes into pacemakers by somatic cell fusion. The idea is to create chemically induced fusion between myocytes and syngeneic fibroblasts engineered to express HCN1 pacemaker channels (HCN1-fibroblasts). HCN1-fibroblasts were fused with freshly isolated guinea pig ventricular myocytes using polye...
متن کاملExpression and function of a biological pacemaker in canine heart.
BACKGROUND We hypothesized that localized overexpression of the hyperpolarization-activated, cyclic nucleotide-gated (HCN2) pacemaker current isoform in canine left atrium (LA) would constitute a novel biological pacemaker. METHODS AND RESULTS Adenoviral constructs of mouse HCN2 and green fluorescent protein (GFP) or GFP alone were injected into LA, terminal studies performed 3 to 4 days late...
متن کاملSelf-Stabilizing Pulse Synchronization Inspired by Biological Pacemaker Networks
We define the “Pulse Synchronization” problem that requires nodes to achieve tight synchronization of regular pulse events, in the settings of distributed computing systems. Pulse-coupled synchronization is a phenomenon displayed by a large variety of biological systems, typically overcoming a high level of noise. Inspired by such biological models, a robust and self-stabilizing pulse synchroni...
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ژورنال
عنوان ژورنال: University Heart Journal
سال: 1970
ISSN: 1998-927X,1998-9261
DOI: 10.3329/uhj.v6i1.7189